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KMID : 1151820130070030213
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Journal of the Korean Society of Radiology
2013 Volume.7 No. 3 p.213 ~ p.219
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An Activation Analysis of Target("used H218O") for 18FDG Synthesis
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Kang Bo-Sun
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Abstract
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Currently, about 35 cyclotrons have been operating in South Korea. Most of them are mainly used for the synthesis of radiopharmaceuticals such as ¹?FDG, which is a cancer tracer for nuclear medicine. Highly enriched H₂¹?O containing up to 98% of ¹?O/O isotope ratio is used as the target for 18F production. The price of the highly enriched H₂¹?O ranges 60~70 USD/g, and all of them have been imported from foreign country in spite of the very expensive price. The target (enriched H₂¹?O) is non-radioactive before the proton beam irradiation. But, the post-irradiation target (used H₂¹?O) must be managed following the National Radiation Safety Regulations, because it turns into radioactive by the radioactivation of the impurities within the target. Recently, nevertheless of the fast increasing amount of used H₂¹?O in accordance with the increasing number of nuclear medicine cases, any activation analysis on the used H₂¹?O have been conducted yet in Korea. In this research, activation analysis have been conducted to confirm the specific radioactivity(Bq/g) of each radioisotopes within the used H₂¹?O. The analysis have been done on the 3 of 20g samples collected from the used H₂¹?O storages at different cyclotron centers. Based on the results, it was confirmed that the "used H₂¹?O" contains gamma emitters such as ??Co, ??Co, ??Co, and ?⁴Mn as well as the considerable amount of beta emitter ³H. It was also confirmed that the only one sample contained over exemption level of gamma emitters while the specific activity of tritium was lower than the exemption level in all samples. The specific activity of radioisotopes were measured different levels in the samples depending on the elapsed time after irradiation. Further study on the activation of the "used H₂¹?O" is definitely necessary, nevertheless the as-is results of this research must be useful in establishing a rational "used H₂¹?O" management protocol.
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KEYWORD
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used O-18 water, 18FDG, cyclotron center, gamma emitter, activation analysis, 3H, tritium, exemption level
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